TECHNOLOGY

What is StemVesicle?

StemVesicle is compound words of “Stemcell” and “Vesicle”, which means vesicles secreted by stem cell.
Stem cell secretes useful components while cultivating and those powerful components are in the form of vesicle.
Vesicles can travel very far, stable and be easily absorbent in terms of its unique feature of bilayer lipid membrane.
Not only human but also animal and plant stem cell secrete useful factors in the vesicle form.
We found this magnificent component ‘StemVesicle from AAPE’, ‘StemVesicle by Coculture’ using human stem cell, ‘StemVesicle by Deer Antler’ using animal stem cell and, ‘StemVesicle by Wild Ginseng’ using plant stem cell.
It is clinically proven for hair regrowth and skin regeneration effect with all our products and used as cosmetic ingredients for its perfect balance.

CONCEPT

AAPE

AAPE,

an abbreviation for Advanced Adipose-derived stem cells Protein Extracts, is a mixture of refined growth factor proteins that is extracted from human adipose-derived stem cells conditioned media.

AAPE maximizes the revitalizing effects of skin and hair follicles and consists of human proteins created by stem cells, natural composition with multi-function such as anti-wrinkle, antioxidant, whitening, hair re-growth and even wound healing effect.

Deer antler is

Deer antler is

a unique organ in mammal, which can be perfectly regenerated even after being cut. Furthermore, Keratin is the main component of deer antler while it is also a major component of human hair. It is well-known material as a natural alternative medicine for invigorating vital energy for thousands years in Asia.

StemVesicle from deer antler contains abundant of hair follicle stimulating factors which are key factors for hair regrowth. It is from the deer antler stem cell conditioned media under the stem cell bio-technology specialized in hair follicle & cell environment.

Wild Ginseng is

Wild
Ginseng is

called as God Plant in natural oriental medicine to maintain a body homeostasis as well as provide vitality. StemVesicle from Wild Ginseng is a natural extract of conditioned media from 100-year-old wild ginseng, which absorbs natural nutrition from the soil of wild mountain.

It secretes abundant of regeneration communication factors such as growth factors, cytokines, extracellular metrics and normalizes skin turn-over cycle. By regeneration and proliferation of fibroblast, it improve skin elasticity, thickness, wrinkles and reconstructs collapsed skin barrier eventually.

StemVesicle by Coculture is

StemVesicle
by Coculture is

the most innovative product based on Prostemics’s stem cell bio-technology of cultivating and stimulating Adipose derived Stem Cell in a decade.

StemVesicle by Coculture activates stem cell of hair and induces differentiation from Adipose Stem Cell to Dermal Papilla Cell.

ARTICLES

“Recently it has emerged that the paracrine functions of mesenchymal stem cells could, at least in part, be mediated by extracellular vesicles”

“Recent animal model-based studies suggest that extracellular vesicles have significant potential as a novel alternative to whole cell therapies. Compared to their parent cells, EVs may have a superior safety profile and can be safely stored without losing function.”

Sweta, Aideen, Matthew, Thomas (2015). Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Molecular Therapy, 23(5):812-3

“Adipose-derived stem cells and its secretory factors are effective for UVB-induced wrinkles, and the antiwrinkle effect is mainly mediated by reducing ultraviolet-B-induced apoptosis and stimulating collagen synthesis of human dermal fibroblasts.”

WS Kim, BS Park, SH Park, HK Kim, JH Sung (2008). Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors. Journal of Dermatological Science, doi:10.1016/j.jdermsci.2008.08.007

“Adipose-derived stem cells have various cytokine-secreting properties and beneficial paracrine effects on surrounding cells or tissues. Recently, paracrine function is considered one of the most important therapeutic benefits of therapy using mesenchymal stem cells”

“Conditioned medium of adipose-derived stem cells (ADSC-CM) led to the increase in proliferation of human dermal papilla cells through the modulation of the cell cycle. In addition, ADSC-CM activated both Erk and Akt signaling pathways, which indicated the enhancement of survival and proliferation of dermal papilla cells”

Won CH. Hair growth-promoting effects of adipose tissue-derived stem cells. J Dermatol Sci (2009), doi:10.1016/j.jdermsci.2009.10.013

“Deer Antler extract promotes hair growth by extending the anagen phase and regulating cell proliferation in the hair follicle region.”

jing-jie Li et at. (2014). Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles. Hindawi, Article ID 878162

“Food-derived exosome-like nanoparticles pass through the intestinal tract throughout our lives”

Songwen, Jingyao, Terje, Xiaoying, Qilong, Hong, Xiaoyu et al. (2013). Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis. Molecular Therapy, 21(7):1345-57

CONTACT US

If you have any question, you can reach us via,

E-mail
inquiry@prostemics.com

Stemvesicle Launching Party
(Oct. 23rd, 2015)